Coenzyme Q10

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Co Q10 (ubiquinone 10) is a ubiquitous coenzyme and the most common of the ubiquinone family in humans. It functions mainly in the mitochondria, where it participates in the electron-transport chain for ATP synthesis during aerobic respiration.

Major sources of CoQ10 is biosynthesis that require the expression of at least a dozen of genes. Thus, mutations or abnormal proteins from any of these genes can lead to deficiency.

Safe oral dose is below 1200 mg/day. Supplementary doses are usually between 100-200 mg/day. It is mostly well tolerated but doses above 1200 mg/day may cause gastrointestinal symptoms, rashes, and headaches.

Supplementary CoQ10 has been studied in reference to some diseases including heart diseases, cancer, and migraine headaches. One metanalysis with a dose range of 30 – 100 mg/day, indicated a 31% reduction in mortality from heart failure, in association with increased exercise capacity. The Canadian Headache Society recommends its use at a dose of 300 mg for prophylactic management of migraine headache. Its use in cancer is controversial and may even interfere with the effectiveness of chemotherapy and radiotherapy.

Pros:

Supplementary CoQ10 may be beneficial in people with low levels in cells, possibly due to reduced synthesis. Similarly, CoQ10 supplementation may benefit some heart failure patients, and those with migraine headaches.

Cons:

More studies are needed to clarify its use in several other diseases.

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