Nicotinamide

Nicotinamide (niacinamide or vitamin B3) is an amide of nicotinic acid. It is part of the cofactor, nicotinamide adenine dinucleotide (NADH/NAD+). This cofactor is crucial to life as it serves as a cofactor for many essential redox reactions including glycolysis, tricarboxylic acid cycle, and the electron transport chain.

Trace amounts of nicotinamide occur in fish, meat, nuts, mushrooms, and some vegetables. The levels in multivitamins range from 20 – 30 mg.

Several studies demonstrate its beneficial effects in some skin conditions. Supplementation with 500 – 1000 my/day reduces the risk of developing nonmelanoma skin cancer and actinic keratosis.

It is used to treat bullous pemphigoid, psoriasis, and nonmelanoma skin cancer. It may benefit patients with acne, rosacea, and atopic dermatitis. It even prevents skin ageing. It is also the treatment for pellagra, a niacin-deficiency condition.

Nicotinamide is well tolerated and has very little side effects.

Pros:

Effective against many skin conditions and may prevent skin ageing. It is well tolerated with little side effects. Should boosts MitoHealth by augmenting mitochondrial energy production.

Cons:

Given its involvement in reduction-oxidation reactions, glycolysis, and the operation of the electron transport chain, it is likely many beneficial effects are yet to be uncovered.

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